Topic: dream -/- mice

Aging, both physiological and pathological, results in a widespread decline in cognitive, sensory, and motor functions. Adult hippocampal neurogenesis is a phenomenon that diminishes with age across various mammalian species and has been proposed as a significant factor linked to age-related cognitive deficits. Our laboratory's preliminary studies reveal that mice lacking the DREAM protein (dream -/-) exhibit cognitive improvement with aging, along with increased neurogenesis and greater development of immature neurons positive for DCX compared to wild-type mice of the same age. To further und