Dynamics of focally hyperconcentrated drug release for non-invasive cortical circuit manipulation
Gizem Aydemir, Paul Johnson, Mehmet Sirin Ozdas, Yitong Li, Mehdi AghiliBehnam, Wolfger von der Behrens, Mehmet Fatih Yanik · FENS Forum 2024
Our group recently developed a technology for non-invasive hyperconcentrated (1’300x) focal drug delivery to the brain without opening the blood-brain barrier (BBB), reducing off-target effects significantly [1]. This study aims to investigate and improve the dynamics of focally hyperconcentrated drug release mechanisms using focused ultrasound (FUS) technology and ultrasound-sensitive drug carriers. Firstly, to achieve high concentration of drug release, we designed and manufactured ultrasound-sensitive drug carriers using microfluidic technology, allowing us to have control over size and con
ePoster · Neuroscience