Role of central amygdaloid alpha-2 adrenergic receptors in the modulation of anxiety in the rat
Miguel Perez de la Mora, Juan Carlos Mondragon-Hernandez, Luis Angel Cruz-Montesinos, Minerva Crespo-Ramirez, Daniel Alejandro Palacios-Lagunas, Dasiel Oscar Borroto-Escuela, Kjell Fuxe · FENS Forum 2024
It is commonly recognized that amygdala plays a critical role in the modulation of anxiety. Furthermore, alpha-2 adrenergic receptor activity has been suggested to be involved in anxiety modulation. The aim of this study was to ascertain whether the central amygdaloid nucleus, which represents the main anxiogenic output of amygdala is involved in such adrenergic actions. Elevated Plus-Maze and Shock-Probe-Burying paradigms were used to study the effects of sterotaxically-infused clonidine, a specific alpha 2 adrenergic agonist on anxiety. DSP-4, a toxin specifically destroying locus coeruleus