Effect of pallidal DBS on the cerebellar cortex of a dystonic model
Fabiana Santana Kragelund, Denise Franz, Marco Heerdegen, Anika Lüttig, Stefanie Perl, Angelika Richter, Rüdiger Köhling · FENS Forum 2024
Aims: Dystonia is a neurological syndrome that alters voluntary muscle control and sustained posture. The most promising targets for deep brain stimulation (DBS) are the subthalamic nucleus or Globus Pallidus internus (GPi). DBS has shown compelling therapeutic advantages in many individuals with primary generalized/segmental dystonia. However, the mechanisms of DBS still need to be clarified. In this context, we were interested in the impact of pallidal DBS on cerebellar activity. Methods: We investigated this topic using a model of primary paroxysmal dystonia (dtsz hamster, 2 months old), im
ePoster · Neuroscience