Topic: dual fibre-photometry

Dopamine (DA) is classically associated with learning and reward prediction error, though it is clear from deficits in the striatal dopaminergic system that DA plays a major, yet unclear, role in controlling motor behaviour. Several recent works have begun to uncover the complex roles DA plays in movement control. We have developed an experimental framework based on a dual fibre-photometry system, EMG recording and a freewheeling linear treadmill to explore the dynamics of dLight readouts during spontaneous locomotion and brief muscle twitches in head-fixed mice. In this work, we find high cor