Topic: Dunn chamber

During cortical development, intrinsic and extrinsic factors regulate how radial glial cells (RGs) proliferate and produce neurons in a highly controlled manner. To date, investigation of the mechanisms regulating radial migration has predominantly relied on studies of cultured cortical slices or employed in utero electroporation strategies. However, these methods are not suitable for investigating the role of gradients of extracellular signals. To address this, we developed an innovative in vitro model where RGs processes support the migration of young pyramidal neurons generated in situ.We p