Compensation by dynamics: Functional connectivity rescued from structural damage by modulating dynamical regime
Samy Castro Novoa, Sophie Benitez-Stulz, Gregory Dumont, Boris Gutkin, Demian Battaglia · FENS Forum 2024
Aging and neurodegenerative diseases, such as Alzheimer's (AD) or Amyotrophic Lateral Sclerosis (ALS), led to widespread degeneration of long-range connections in cortical structural connectivity (SC). These damages manifest as losses in connections or demyelination of axons. When the SC of the brain is damaged, the functional connectivity (FC, i.e. the dynamic interactions and information exchange between distinct brain regions) is locally and globally perturbed. Despite the close correlation between SC and FC, they are not identical; FC exhibits greater flexibility and can reorganize in resp
ePoster · Neuroscience