Topic: E/I-balance

Activation of hippocampal inhibitory pathways is essential for maintaining the balance between excitation and inhibition during hippocampal information processing. Somatostatin (SOM) and Parvalbumin (PV) positive GABAergic neurons are two major classes of interneurons in the hippocampus, providing strong dendritic and peri-somatic inhibition to excitatory neurons, respectively. It is well known that exposure of mice to an enriched environment (EE) reliably increases performance on hippocampus-dependent learning and memory tasks. However, the mechanisms underlying the behavioral improvements an