RNF10 role in synaptic plasticity and Alzheimer disease
Jose Ignacio Gomez Blanco, Laura D'Andrea, Silvia Pelucchi, Silvia Pedretti, Elisa Zianni, Nico Mitro, Monica Di Luca, Elena Marcello · FENS Forum 2024
RNF10 is a protein with multiple cellular functions. It has been described as a E3-Ubiquitin ligase, with a key quality-control role during the initiation of translation in the early regulatory ribosome ubiquitylation (RQC). In addition, RNF10 plays in neurons a role as a synaptonuclear messenger, involved in the NMDA receptors (NMDAR) signaling cascade. RNF10 binds to the C-terminal region of the GluN2A subunit of the NMDAR and its translocation from the synapse to the nucleus translates synaptic NMDAR activation into gene expression changes. RNF10 is crucial in the physiology of the neurons,
ePoster · Neuroscience