Temporal evolution of traumatic memory engrams in a mouse model of early-life stress
Maelle Certon, Maxime Liberge, Wissam El-Hage, Catherine Belzung, Arnaud Tanti · FENS Forum 2024
Early-life adversity (ELA) is a leading risk factor for developing mental disorders such as depression or anxiety in adulthood. Some of its anatomical and molecular correlates were described under multiple stress paradigms, acute and chronic alike, in various species. However it is unclear how the cellular substrate of traumatic memories associated with ELA evolves through life and can participate in its behavioral outcome. To allow lifelong tracking of neuronal populations recruited during early-life stress we used FosTRAP2 mice in a juvenile (P21) social defeat model (jSD), in which neuronal
ePoster · Neuroscience