Neonatal CA3 hyperexcitability drives hippocampal epileptogenesis in SCN2A epileptic encephalopathy
Daniil Kirianov, Yana Reva, Katharina Ulrich, Birgit Engeland, Stephan Marguet, Dirk Isbrandt · FENS Forum 2024
SCN2A encodes the Nav1.2 voltage-gated sodium channel subunit, which is crucial for the initiation, propagation, and backpropagation of action potentials. During human and mouse brain development, Nav1.2 is the dominant axonal Nav isoform. Genetic SCN2A variants are associated with neurodevelopmental disorders such as epilepsy, ASD, ID, and schizophrenia. Nav1.2 gain-of-function variants have been shown to cause epilepsy and SUDEP, but the network changes driving epileptogenesis during development are not known. Given the dominant role of Nav1.2 during hippocampal development we hypothesize th
ePoster · Neuroscience