Involvement of entorhinal input to the hippocampus in processing “what” and “where” information in twin variants of a memory task
Ana Belen de Landeta, Lucie Descamps, Clifford Kentros · FENS Forum 2024
Episodic memory (EM), the remembrance of an event with spatiotemporal (what-where-when) information relies on the hippocampus (HP) and the entorhinal cortex (EC). The superficial layers of the EC provide the primary input to the HP via the perforant path, so we use a mouse line capable of expressing chemogenetic inhibitors in a particular set of projection neurons of EC Layer II (EC stellate and fan cells) to examine the precise role played by EC inputs in different forms of episodic memory. For this we employ an episodic memory task with both olfactory and spatial twin variants. Both are iden
ePoster · Neuroscience