Lesion-induced neuroblasts in the striatum are LGE-class interneurons and are not fated towards adult striatal neuron cell types
Giulia Nato, Marco Fogli, Valentino Cerrato, Valentina Proserpio, Salvatore Oliviero, Paolo Peretto, Annalisa Buffo, Federico Luzzati · FENS Forum 2024
In the adult brain, subsets of astrocytes act as neural stem cells in two specialized niches, the sub-ventricular zone and hippocampal dentate gyrus, where they produce olfactory bulb interneurons and dentate gyrus granule cells throughout life. In specific conditions the genesis of new neurons can occur also outside these niches in the adult brain parenchyma. This ectopic neurogenesis is prominent in the striatum where it occurs in both physiologic, in adult rabbits and adolescent guinea pigs, or pathologic conditions, such as mouse models of both progressive and acute neuronal degeneration.
ePoster · Neuroscience