Chemotherapy alters the Kolmer cell of the choroid plexus
Parisa EmamiAref, Lucie Kubičková, Babak Bakhshinejad, Petr Dubový, Marek Joukal, Alemeh Zamani · FENS Forum 2024
Paclitaxel, a well-known anti-cancer drug, hinders cell division by stabilizing microtubules. Despite its effectiveness, paclitaxel causes neuropathic pain, possibly due to its impact on the immune system. The study investigated how paclitaxel affects CP macrophages, important for the blood-cerebrospinal fluid barrier. It focused on two types of Kolmer cell macrophages in a model of paclitaxel-induced neuropathic pain. Wistar rats received either paclitaxel or its vehicle (Ethanol and chromophore). Brains, including those from naïve rats, were collected at different intervals (1, 7, 14, and 21
ePoster · Neuroscience