Effort-based decision-making versus spontaneous foraging tasks reveal divergence in antidepressant effects on motivation in mice
Caterina Marangoni, Foteini Xeni, Emma Robinson, Megan Jackson · FENS Forum 2024
Antidepressant drugs are beneficial for many of the symptoms of depression, but impairments in reward and motivation often remain or become worse. The effort-based foraging (EBF) and the effort-for-reward (EfR) tasks target different aspects of reward processing and motivation. This study investigated the effects of different antidepressants on effort-related decision-making (EfR) and motivation to engage with natural foraging (EBF). 2 cohorts of 16 and 24 C57bl/6J male mice were used in fully randomised, counterbalanced within-subject designs for acute pharmacological studies (escitalopram, v
ePoster · Neuroscience