Age effect on the willingness to work for sucrose in male rats: Involvement of the cerebral dopamine neurotrophic factor
Régulo Olivares García, Carla Carratalá-Ros, Edgar Arias-Sandoval, Andrea Martínez-Verdú, Paula Matas-Navarro, Jana Lubec, Gert Lubec, John D. Salamone, Mercè Correa · FENS Forum 2024
Effort-related symptoms, such as anergia and fatigue, play a central role in many psychopathologies and neurological diseases. The mesolimbic dopamine (DA) pathway projecting to nucleus accumbens, (NAcb) modulates behavioral activation and effort exertion. Depletion of DA levels in Nacb leads to anergia and influences choices toward less effortful demanding options. DA function seems to be diminished with age. Our laboratory has developed behavioral tasks for rodents, including the PROG/sucrose task, for the study of effort-related choices linked to DA signaling in NAcb. Male Wistar rats of di
ePoster · Neuroscience