Propionic acid activates anti-inflammatory processes and induces adult phenotype changes in Schwann cells
Niklas Rilke, Mona Shaygan Tabar, Baffour Sarpong, Katharina Lemhoefer, Clarissa Lohmann, Alina Blusch, Anna Meichsner, Zhixiao Wu, Melissa Sgodzai, Adriana Rehm, Pia Renk, Barbara Gisevius, Anna-Lena Fisse, Jeremias Motte, Thomas Grüter, Konstanze Winklhofer, Ralf Gold, Kalliopi Pitarokoili · FENS Forum 2024
The chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease affecting myelin and neural structures of the PNS. In recent studies, propionic acid (PA) showed anti-inflammatory and disease modifying effects in multiple sclerosis patients. Additionally, PA exerted neuroprotective and neuroregenerative effects in PNS in vitro cell cultures of Schwann cells (SC) and dorsal root ganglia (DRG). In this study, we investigate the potential effects of PA on SC derived from rats sciatic nerve. First, SC were treated with IFNγ to induce MHC-II receptor expression, which was measu
ePoster · Neuroscience