Topic: eIF2α

Spinocerebellar ataxia type 2 (SCA2) is a rare neurodegenerative disease that arises from a mutation within the ATXN2 gene characterised by abnormally long CAG trinucleotide repeats. The mutant gene product is the ataxin-2 protein, which bears an expanded glutamine tract. The mutant protein is known to disrupt molecular pathways within cells, leading to cellular death and neurodegeneration within specific brain regions.To cope with disrupted pathways, cells have mechanisms such as the Integrated Stress Response (IRS), which help cells resolve stress situations by reorganising translation to pr