Topic: electrical potentials

Most computational models of neurons assume temporally constant ion concentrations and zero extracellular potentials. This paradigm limits our ability to computationally investigate the impacts of changing ion concentrations and extracellular potentials on the dynamics of single cells and networks. We previously developed the first neuron model to include both intra- and extracellular ion concentrations and electrical potentials in a biophysically consistent manner and illustrated how this influenced the dynamics of the cell (Sætra et al. 2020, PLoS Comp Biol). However, the neuroscience commun