Properties and predictive potential of the pre-ictal oscillatory dynamics in an ex vivo model of seizure-like activity in the different hippocampal subregions
Lida Vagiaki, Dionysios Xydias, Maria Kefalogianni, Sotiris Psilodimitrakopoulos, Emmanouel Stratakis, Kyriaki Sidiropoulou · FENS Forum 2024
Seizure-like activity (SLA) results from synchronous neuronal activity in the mouse hippocampal subregions, namely: CA1, CA3 and DG. While many studies have proved the anticonvulsant properties of the administration of anti-epileptic drugs, such as diazepam (DZP), a GABA-A receptor agonist, and carbamazepine (CBZ), a sodium channel blocker, their role in modulating the oscillatory patterns within these three regions remains unclear. Furthermore, the role of oscillatory dynamics in the pre-ictal period in predicting the emergence of a seizure events require further investigation. In our study,
ePoster · Neuroscience