Topic: elevated plus-maze

The ventral hippocampus has emerged as a central hub for the orchestration of negative effects. We employed wireless amperometric O2 measurements in freely moving rats as a surrogate readout for changes in neuronal activity with translational value for fMRI studies in humans. From the Research Domain Criteria (RDoC) matrix, here, mainly one branch, namely the negative valence system is addressed using a modified Elevated Plus-Maze, male Wistar rats are tested under controllable (modified Elevated T-Maze, mETM with free exploration of one open and two closed arms) and uncontrollable (Open Arm C

It is commonly recognized that amygdala plays a critical role in the modulation of anxiety. Furthermore, alpha-2 adrenergic receptor activity has been suggested to be involved in anxiety modulation. The aim of this study was to ascertain whether the central amygdaloid nucleus, which represents the main anxiogenic output of amygdala is involved in such adrenergic actions. Elevated Plus-Maze and Shock-Probe-Burying paradigms were used to study the effects of sterotaxically-infused clonidine, a specific alpha 2 adrenergic agonist on anxiety. DSP-4, a toxin specifically destroying locus coeruleus