Topic: embryonic CSF

Embryonic neurodevelopment, which occurs in the sterile uterine environment, has recently been shown to be modulated by signals from the maternal gut microbiota. We hypothesised this may occur through microbial signalling to radial glial (RG) cells, which generate cortical neurons, and function as a scaffold along which new-born neurons migrate. Therefore we aimed to study the effect of maternal gut microbiota depletion during pregnancy on RG-led neurodevelopment. Female mice were treated with an antibiotic cocktail prior to and throughout pregnancy to deplete their gut microbiota. Embryonic b