Emotional and blood-brain barrier alterations precede cognitive dysfunction in a mouse model of Alzheimer's disease
Guillaume Benhora-Chabeaux, Damien Mor, Lidia Cabeza, Thibaut Nicod, Bahrie Ramadan, Christophe Houdayer, Adeline Etievant, Fanchon Bourasset · FENS Forum 2024
Alzheimer's disease (AD), the leading cause of dementia, has traditionally been described as a pathology primarily affecting cognitive function with impaired neuronal and glial functioning. However, recent studies suggest that more than 75% of patients exhibit early emotional perturbations and that cerebrovascular remodeling could underlie these cognitive and emotional impairments. The aim of this study was to characterize the time of onset of anxio-depressive-like phenotype in a mouse model of AD and their potential correlation with blood-brain barrier (BBB) dysfunctions already described by
ePoster · Neuroscience