Topic: Emotional residue

Emotional residue from past or anticipated future events is common and can contribute to anxiety if exacerbated. The orbitofrontal cortex is a region that is widely implicated in anxiety disorders as well as future predictions. Here we demonstrate a double dissociation within this region, where the lateral orbitofrontal cortex (lOFC) is specialized for prediction of future states, setting it apart from its medial counterpart (mOFC). Fifteen participants rated their arousal (Fig1a) while watching a movie under the scanner with a few 25-second rests inserted strategically. These were categorize