The transcriptomic landscape of spinal V1 interneurons implicates a specific molecular subset in the control of locomotor speed
Alexandra Trevisan, Katie Han, Phillip Chapman, Anand Kulkarni, Jennifer Hinton, Cody Ramirez, Ines Klein, Mariano Gabitto, Vilas Menon, Graziana Gatto, Jay Bikoff · FENS Forum 2024
Neural circuits in the spinal cord are composed of diverse sets of interneurons that play a crucial role in shaping motor output. Despite progress in revealing the cellular architecture of the spinal cord, the extent of cell type heterogeneity within cardinal interneuron classes remains unclear, hindering our understanding of the organization of the spinal motor infrastructure. Through a focus on a single cardinal class of spinal interneurons, here we present a comprehensive atlas of V1 interneuron diversity across postnatal development using single-nucleus transcriptomics. We find that cell-t
ePoster · Neuroscience