Topic: endfeet processes

The nucleus accumbens (NAc), a brain region implicated in the regulation of anxiety-related behaviors, has been found to be susceptible to blood brain barrier (BBB) permeability in psychopathologies. Additionally, the positive effects of testosterone on BBB function and anxiety related behaviours is still controversial. In this study, exploiting natural phenotypic variation in anxiety-like behaviors in outbred Wistar male rats, we aimed at investigating whether testosterone plays a role in anxiety-related BBB disfunction. We classified animals as high (HA) or low anxious (LA) according to the