Topic: endocannabinoid-mediated long-term potentiation

One-shot learning is a crucial mechanism for survival and adaptation, enabling rapid acquisition of knowledge from a single experience [1]. Here, we investigated the synaptic plasticity associated with one-shot learning in vivo, focusing on endocannabinoid-mediated long-term potentiation (eCB-LTP) at cortico-striatal synapses [2]. We recorded neural activity in the cortex and striatum of behaving mice subjected to an uncomfortable stimulus in an arena using Neuropixel probes. This task was designed to induce avoidance behavior after a single encounter of the stimulus, thus modeling one-shot le