Topic: endogenous antioxidant systems

Epilepsy is a common neurological disorder that affects 1% of the global population and significantly burdens patients and society. Many epilepsies are acquired following brain injury and no effective prophylaxis or cure exists. Accumulating evidence suggests that oxidative stress plays a critical role in the development of epilepsy, and that pharmacological targeting of oxidative stress can prevent spontaneous seizures. However, non-specific antioxidant therapies may disrupt the physiological balance of oxidants/antioxidants, highlighting the need for targeted intervention. Here, we used AAV