Topic: endogenous bursting

Nowadays, 1.5 billion people suffer from chronic pain. Current neuropharmacology and neurostimulation treatments are associated with suboptimal efficacy, due to a lack of understanding of the pain system. A major contributor to many persistent clinical pain states is the phenomenon of central sensitization---a state of hyperexcitability of the pain system resulting from changes in the properties of neurons and circuits within the dorsal horns of the spinal cord. Although spinal cord circuits and their plasticity are challenging to study experimentally, only a handful of computational studies