Topic: endogenous serotonin activity

Serotonin has been linked to a broad array of behavioral and affective states, yet technological limitations have historically constrained the interrogation of this circuitry. Originating from the raphe nuclei, the serotonin system exhibits distinct projections to both cortical and subcortical networks, engaging in widespread communication with downstream targets. Selective serotonin reuptake inhibitors (SSRIs) are among the most commonly prescribed pharmacological treatments for depression/anxiety, yet it is mostly unknown how they impact endogenous serotonin function. Notably, SSRIs take app