In ovo RNAi as an efficient tool to explore molecular mechanisms of neural circuit formation in the cerebellum of chicken embryos
Aikaterini (Katerina) Koutourlou, Martina Schaettin, Esther T. Stoeckli · FENS Forum 2024
The cerebellum, traditionally associated with motor control, is now implicated also in higher cognitive functions. Patients exhibiting impaired cognition display cerebellar abnormalities, reported in disorders such as autism spectrum disorder (ASD), intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), or schizophrenia. Purkinje cell migration deficits, volumetric changes and structural anomalies in the cerebellum have been observed in these conditions. This project aims to elucidate the connection between cerebellar circuit formation and neurodevelopmental disorders t
ePoster · Neuroscience