Topic: endophilins-A

Dopaminergic neuron functions rely on active synaptic vesicle dynamics and proteostasis. Deficientendocytosis due to lack of endophilins-A, key endocytic adaptors, alters the expression of genesassociated with ataxia, Parkinson's disease and protein homeostasis. Fbxo32, a E3-ubiquitin ligaserequired for muscle atrophy but also expressed in the brain, was shown to be up-regulated inendophilin mutants. Hence, we aimed to investigate the dopaminergic system alterations in theendophilins-A murine model, and explore the effects of Fbxo32 genetic modifications on dopaminedegeneration in this mammali