Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in an Alzheimer’s disease mouse model
Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato, Micaela Zonta · FENS Forum 2024
Alzheimer’s disease (AD) is a chronic incurable neurodegenerative disorder characterized by progressive memory loss and cognitive dysfunctions. Brain function is governed by dynamic interactions between neurons and glial cells. Over the last decades it has been shown that calcium dynamics in astrocytes represent a fundamental signal that through gliotransmitter release regulates synaptic plasticity and behaviour. Here, by using cutting-edge techniques including 2-photon Ca2+ imaging, electrophysiology and behavioural memory tests, we present a longitudinal study in the PS2APP mouse model of AD
ePoster · Neuroscience