Topic: endosomal pathway

RNA localization is a key mechanism to control protein abundance at the subcellular level. Neurons heavily rely on this process for their proper development and function, but how specific mRNAs reach their site of translation remains poorly understood. Here, we investigated the role of the endosomal pathway in controlling RNA localization and translation in neurons. Through rapid isolation of endosomal compartments followed by RNA sequencing, we first found a vast repertoire of mRNAs associated with endosomes in developing neurons, with functions associated with various organelles and molecula