Stress promotes peripheral immune interactions at the brain endothelium
Johana Alvarez, Flurin Cathomas, Kenny L Chan, Lyonna F Parise, Aarthi Ramakrishnan, Molly Estill, Scott J Russo · FENS Forum 2024
Chronic psychosocial stress is a significant risk factor for the development of stress-associated psychiatric disorders, including major depressive disorder, which causes profound debilitation and has increasing worldwide prevalence. Pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders, such as elevated levels of proinflammatory immune cells and cytokines in circulation. Endothelial cells are critical components of the blood-brain barrier (BBB), as they interface directly with immune cells and their released factors, which can enter the
ePoster · Neuroscience