Intracranial atherosclerotic plaque and wall enhancement reflect the endothelial damage and arterial inflammatory level through ECM-1 levels and CCR5 expression in monocytes
Jesus Agulla, Beatriz Gómez-Vicente, María Hernández-Pérez, Rebeca Lapresa, Mercedes De Lera, Ana I. Calleja, Elisa Cortijo, Alicia Sierra, Javier Reyes, Margarita Rodríguez-Velasco, Angeles Almeida, Juan F. Arenillas · FENS Forum 2024
Intraplaque post-contrast enhancement (PCE) on high-resolution magnetic resonance imaging (HR-MRI) could help personalize the risk of patients with intracranial atherosclerotic disease (ICAD). We have analyzed whether plaque and wall PCE is related to endothelial damage through ECM-1 serum levels and the arterial inflammation indicated by the expression of CCR5 in a subpopulation of monocytes.We designed a prospective, longitudinal study including symptomatic ICAD patients and asymptomatic subjects with a very-high vascular risk. Study participants underwent artery-wall HR-MRI and blood sample
ePoster · Neuroscience