Topic: endotoxin-induced sickness

Psychological and somatic sickness symptoms are common adverse side effects of immunotherapy and chemotherapy. Due to the unpleasantness of these symptoms, many patients develop negative treatment expectations during the course of therapy and often show anticipatory behavioral and physiological responses upon re-exposure to treatment-related cues. Despite broad clinical implications, the underlying molecular and neurobiological mechanisms of sickness-induced negative treatment expectations and their physiological consequences are largely unknown and difficult to study in humans. This calls for