Acute stress via retrograde endocannabinoid signaling disrupts engram ensemble specificity to generalize threat memory in mice
Sylvie Lesuis, Annelies Hoorn, Mario van der Stelt, Brandon Walters, Paul Frankland, Sheena Josselyn · FENS Forum 2024
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories for events are encoded by a sparse ensemble of principal neurons active during an event, termed an engram ensemble. Using engram labeling tools, molecular sensors, optogenetics and CRISPR-Cas9 gene editing in specific neuronal populations we examined the molecular and circuit processes mediating stress-induced threat memory overgeneralization in mice. We found that stress, acting via corticosterone, increases the density of engram ensembles supporting a threat memory and this less sparse engra
ePoster · Neuroscience