Characterization of the cerebral dopamine neurotrophic factor (CDNF) in nucleus accumbens of rodents
Merce Correa, Carla Carratala-Ros, Paula Matas-Navarro, Andrea Martínez-Verdú, Regulo Olivares-Garcia, Edgar Arias-Sandoval, John D. Salamone · FENS Forum 2024
Nucleus Accumbens (Nacb) dopamine (DA) regulates behavioral activation and effort-related decision-making in motivated behaviors. DA depletion has been shown to induce anergia and fatigue in effort-based decision tasks. The Cerebral Dopamine Neurotrophic Factor (CDNF) promotes the survival and function of dopaminergic neurons, and it is used to restore midbrain dopaminergic neurons in animal models of Parkinson’s disease. However, little is known about the role of CDNF in Nacb and if this neurotrophic factor can be affected by factors such as sex or age, behavioral manipulations or drugs that
ePoster · Neuroscience