Exploring cortico-hippocampal dynamics during sharp-wave ripples with months-long tracking of neuronal ensembles via ultra-flexible tentacle electrodes
Peter Gombkoto, Tansel Baran Yasar, Alexei Vyssotski, Angeliki Vavladeli, Linus Meienberg, Valter Lundegardh, Wolfger von der Behrens, Mehmet Fatih Yanik · FENS Forum 2024
Cortico-hippocampal interactions during hippocampal sharp-wave ripples (SPW-Rs) play a crucial role in memory consolidation. Hippocampal-dependent memories undergo replay during SPW-Rs, facilitating coordinated ensemble reactivation in the neocortex. This orchestrated mechanism is essential for transferring memory traces from the hippocampus to long-term storage in the neocortex. Following memory consolidation in the neocortex, it is hypothesized that downstream neuronal ensembles are stabilized in diverse cortical regions. The stability of neuronal ensembles across several months has not been