Topic: entropy rate

Quantification of information content and its temporal variation in intracellular calcium spike trains in neurons helps one understand functions such as memory, learning, and cognition. Such quantification could also reveal pathological signaling perturbation that potentially leads to devastating neurodegenerative conditions including Parkinson's, Alzheimer's, and Huntington's diseases. Accordingly, the estimation of entropy rate, an information-theoretic measure of information content, assumes primary significance. However, such estimation in the present context is challenging because, while