Probing memory formation and retrieval in hippocampal networks
Ivan Montiel, Cantin Ortiz, Desdemona Fricker, Christoph Schmidt-Hieber · FENS Forum 2024
How does the hippocampus know when to store a new memory?We hypothesize that when animals transition into a novel environment,a transient small increase in Dentate Gyrus(DG) activity triggers downstream circuits to establish new neuronal representations.To empirically test this hypothesis,we focus on understanding how neuronal population activity in hippocampal subregions responds to transitions from a familiar(F) to a novel(N) environment. We use an immersive virtual reality setup adapted for rodent head-fixed navigation (n= 6mice).After five consecutive daily training sessions in the familia
ePoster · Neuroscience