Cognitive flexibility and anterior cingulate gray matter volumes correlate with serum levels of brevican in healthy humans
Anni Richter, Margarita Darna, Björn H. Schott, Constanze I. Seidenbecher · FENS Forum 2024
The brain’s Extracellular Matrix (ECM) is a unique 3-dimensional macromolecular network implicated in homeostasis, neuronal plasticity, and aging-related cognitive alterations. Based on previous animal studies we hypothesized that neural ECM molecules like the proteoglycan brevican (BCAN) affect cognitive flexibility (CFL) also in humans. We addressed this hypothesis in young and older healthy human subjects by assessing flexibility performance and gray matter volumes (GMV) in dorsal anterior cingulate cortex (dACC), a key structure for cognitive control, together with serum concentrations of
ePoster · Neuroscience