A REM-active basal ganglia circuit that regulates anxiety
Wei Ba, Mathieu Nollet, Xiao Yu, Chunyu Yin, Sara Wong, Andawei Miao, Esteban J Beckwith, Edward C Harding, Ying Ma, Raquel Yustos, William Wisden, Nicholas P Franks · FENS Forum 2024
REM sleep has been hypothesized to promote emotional resilience, but no neuronal circuitsmediating this have been identified. We find that in mice, somatostatin (Som) neurons in theentopeduncular nucleus (EPSom)/internal globus pallidus are predominantly active during REMsleep. This unique REM activity is necessary and sufficient for maintaining normal REM sleep.Inhibiting or exciting EPSom neurons reduced or increased REM sleep duration, respectively.Activation of the sole downstream target of EPSom neurons, Vglut2 cells in the lateral habenula(LHb), increased sleep via the ventral tegmental
ePoster · Neuroscience