Unlocking the role of Enhancer of Polycomb Homolog 1 (EPC1) in brain function
Álvaro Ballesteros-González, Candela Barettino, Antonia Ruiz-Pino, Binnaz Yalcin, Khalil Khass Youssef, Juan Paraíso-Luna, Yixin Dong, Haruhiko Koseki, Ángel Barco, Felix Leroy, Antonio Gil-Nagel, Ángel Aledo-Serrano, Isabel Del Pino · FENS Forum 2024
Precise control of gene expression through epigenetic mechanisms is vital for proper brain development. Genetic variations affecting these epigenetic processes have been linked to various neurodevelopmental disorders characterized by intellectual disability and developmental delay. However, our understanding of the landscape of epigenetic factors orchestrating gene expression during brain development remains incomplete. Here, we investigate Epc1, a scaffold protein of the histone acetyltransferase complex NuA4/Tip60, whose role in the central nervous system remains unexplored. Using a knockout
ePoster · Neuroscience