Role of EphrinB3 in POMC neurons in the control of energy and glucose homeostasis
Clémentine Pajot, Gwenaël Labouèbe, Yann Emmenegger, Angélique Vaucher, Bernard Thorens, Sophie Croizier · FENS Forum 2024
Proopiomelanocortin neurons have been primarily described as controlling feeding behavior, but accumulating evidence also showed a crucial role of these neurons in the control of glucose homeostasis. For this, and in addition of being able to sense peripheral signals, POMC neurons receive direct upstream excitatory (glutamate) and inhibitory (GABA) inputs coming from a plethora of brain areas. Remarkably, EphrinBs (EphrinB1, B2, B3) proteins are well-known actor of glutamatergic synapse formation and plasticity. A study from our group showed that the modulation of EphrinB1 a during development
ePoster · Neuroscience