DNA methylation pattern changes after exposure to delta-9-tetrahydrocannabinol (THC) in human peripheral blood mononuclear cells
Kerda Pulk, Kelli Somelar-Duracz, Kaili Anier, Anti Kalda · FENS Forum 2024
Cannabis is among the most used illicit substances in the world, and it is estimated that around 10% of regular cannabis users are susceptible to developing cannabis use disorder (CUD). Our study aimed to clarify the effect of delta-9-tetrahydrocannabinol (THC) on epigenetic DNA modifiers conducting DNA methylation and demethylation (DNMTs and TET enzymes) on human peripheral mononuclear cells (PBMCs) in vitro. Additionally, we profiled the genome-wide effect of THC and assessed if any genes with marked changes in methylation or hydroxymethylation could be identified. Changes in DNA methylatio
ePoster · Neuroscience