Unique frequency and excitability characteristics seen for 5-9 Hz oscillations preceding absence seizures
Eleni Nikalexi, Thomas Budde, Thomas Seidenbecher, Hans-Christian Pape, Annika Lüttjohann · FENS Forum 2024
Spike-wave-discharges (SWD) are the electrophysiological hallmark of absence epilepsy. The leading theory on SWD generation suggests a seizure onset-zone in the deep somatosensory cortex (S1) with 5-9Hz oscillations often preceding SWDs (preictally). These may act as biomarkers, priming distant cortical regions, with the involvement of the centromedian thalamic nucleus (CM). However, these oscillations are also observed interictally. Our study aimed to characterize preictal and interictal 5-9Hz oscillations, exploring power variations across brain-regions. Additionally, we investigated if inte
ePoster · Neuroscience