Topic: epileptic encephalopathies

Newly discovered group of natural antisense long non-coding RNAs, known as SINEUPs, exhibits the ability to ameliorate defective gene expression by enhancing mRNA translation. A subgroup of severe and drug resistant forms of epileptic encephalopathies (EEs) have been associated to the haploinsufficiency of the GABRA1 gene that, by coding for the α1 subunit of the main inhibitory synaptic receptor, leads to impaired GABAergic inhibition. By taking advantage of a heterozygous α1 knock-out mouse model of epilepsy (het-α1 KO), we exploit SINEUP approach to restore GABAergic inhibitory deficits. Co