Cerebral malaria leads to persistent microglial activation, long-term behavioural changes and electrographic seizures in mice
Simone Mehler, Ina Leiter, Wolfgang Härtig, Jens Bankstahl, Bernd Lepenies, Marion Bankstahl · FENS Forum 2024
Aims: Survivors of cerebral malaria (CM) might develop lifelong sequelae such as cognitive deficits, altered behaviour or epilepsy. Animal models are needed to understand the underlying pathophysiology and to develop preventive or ameliorating therapies. Therefore, in this study we aimed to establish a mouse model reflecting consequences of CM. Methods: To ensure survival, C57BL/6 mice infected with P. berghei ANKA (PbANKA) were closely monitored for parasitaemia and clinical signs of CM, and rescued by artesunate treatment. Following electrode implantation, repetitive EEG-video monitoring was
ePoster · Neuroscience